Lein Lab: Our most valuable asset - the people who work here

Come see us at SOT!

Monday March 11

Neurotoxicity: Neurodegeneration, 11:45 AM - 1:45 PM

Mei-Yung Chen 
Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer’s disease-relevant phenotypes in a genetically susceptible rat model
Abstract Number/Poster Board number: 3146/P251

Chemical Threats and Bioterrorism, 2:15 - 4:15 PM 

Pedro Negri Bernardino
Sustained blood-brain barrier disruption associated with claudin-5 dysregulation in a rat model of acute organophosphate intoxication
Abstract Number/Poster Board number: 3577/P865

Chelsea Unkel
Spatiotemporal profile of IL-1ß following acute intoxication with diisopropylfluorophosphate (DFP) in adult male and female Sprague Dawley rats
Abstract Number/Poster Board number: 3579/P867

Peter Andrew
Changes in glial phenotypes following acute intoxication with the organophosphate diisopropylfluorophosphate
Abstract Number/Poster Board number: 3580/P868

Jeremy MacMahon
Evaluating soluble epoxide hydrolase as a neuroprotective therapeutic target for mitigating adverse neurological sequelae associated with acute diisopropylfluorophosphate (DFP) intoxication
Abstract Number/Poster Board number: 3582/P870

Audrey Luo
Seizure inhibition mitigates blood-brain barrier impairment in a male rat model of acute organophosphate intoxication
Abstract Number/Poster Board number: 3584/P872

Xiuzhen Liu 
Treatment with midazolam or allopregnanolone singly or in combination did not mitigate neuropathology in mice after tetramethylenedisulfotetramine (TETS)-induced status epilepticus
Abstract Number/Poster Board number: 3587/P875

Tuesday March 12

Symposium The State of the Science Linking Environmental Chemicals to Age-Related Neurocognitive Decline, 8:00 – 10:45 AM         

Pamela J Lein 
The effects of chronic exposure to ambient traffic-related air pollution on Alzheimer’s Disease phenotypes in wildtype and genetically predisposed male and female rats

Air Pollution Toxicology, 9:15 - 11:15 AM

Heui Hye Park
Differential effects of traffic-related air pollution on cytokine levels in the plasma and lung of female TgF344-AD rats
Abstract Number/Poster Board number: 4017/P550

Neurotoxicity: Developmental I, 2:15 - 4:15 PM

Jessie Badley
PCB 37 causes sex-dependent changes in neuronal cell apoptosis, axonal growth and dendritic arborization in primary rat cortical neuron-glia cocultures
Abstract Number/Poster Board number: 3808/P310

Rebecca Wilson
Developmental exposure to the Fox River mixture of polychlorinated biphenyls (PCBs) modulates cellular and molecular endpoints relevant to behavioral phenotypes in juvenile male and female mice
Abstract Number/Poster Board number: 3810/P312

Wednesday March 13

Advancements in Utilizing Zebrafish-Based Behavioral Assays for Detecting Developmental Neurotoxicity and Understanding Associated Cellular and Molecular Changes, 8:00 – 11:00 AM

Pamela J. Lein 
Studying chemical-induced seizures in larval zebrafish

Empowering Career Growth Through Effective Mentoring and Networking for Toxicologists, 11:00 AM – 12:20 PM

Pamela J. Lein
Respective roles of mentor and mentee during critical transitions in academia

Thursday March 14

Late-Breaking Abstracts, 8:30 - 11:30 AM

Rosalia Mendieta 
Behavioral characterization of juvenile male and female transgenic mice expressing human cytochrome P450 2A6 or 2B6
Abstract Number/Poster Board number: 5086/P187

Yi-Hua Tsai 
Trolox mitigates neuronal senescence but not neuroinflammation in adult male rats acutely intoxicated with diisopropylfluorophosphate
Abstract Number/Poster Board number: 5115/P216

Maria A. Muñoz
Effects of acute organophosphate intoxication on neurodegeneration and an immunohistochemical biomarker of neuronal activity in the juvenile rat brain
Abstract Number/Poster Board number: 5119/P220

Nathifa Nasim
Effects of different components of traffic-related air pollution on hippocampal amyloid deposition in a transgenic rat model of Alzheimer’s disease
Abstract Number/Poster Board number: 5203/P304