Lein Lab: Our most valuable asset - the people who work here

Our research grants

UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
U54 NS127758 Lein (PI) 07/01/2022 - 06/30/2027
Current medical countermeasures for acute organophosphate intoxication can prevent death, but are unable to fully protect against the longterm adverse neurological consequences (progressive brain injury, cognitive impairment, spontaneous recurrent seizures) unless administered within minutes of exposure, which is an unlikely scenario in the event of accidental, suicidal or terrorist-related exposures. The Center seeks to identify and develop novel disease-modifying therapeutic strategies that can be administered in hours to months after exposure to delay the onset and/or reduce the severity of chronic neurotoxic effects.

Molecular and Cellular Basis of PCB Developmental Neurotoxicity 
R01 ES014901 (Lein (Contact) and Lehmler (MPI)) 12/01/2020 – 10/31/2025
This research project quantifies the developmental neurotoxicity of lower-chlorinated polychlorinated biphenyls (LC-PCBs) found in the human gestational environment and investigates how metabolism by human cytochrome P450 enzymes influences neurotoxic outcomes in experimental animals exposed to LC-PCBs in the maternal diet throughout gestation and lactation.

UC Davis MIND Institute IDDRC
P50 HD103526 (Abbeduto) 07/01/2020-06/30/2025
The MIND Institute IDDRC supports ground-breaking studies of the early behavioral indicators of autism spectrum disorder (ASD); the role of immune disfunction in ASD risk; interactions between genetic susceptibilities and exposure to teratogens in risk for ASD and IDD; the range of phenotypes associated expansions in the FMR1 gene; structural and functional brain abnormalities underlying ASD, fragile X syndrome (FXS), chromosome 22q11.2 deletion syndrome (22q), and other IDD conditions.

UC Davis Environmental Health Science Core Center 
P30 ES023513  (Hertz-Picciotto) 05/05/2015 – 03/31/2025
The overarching goal of the UC Davis Environmental Health Sciences Core Center is to expand the scope, innovation, and impact of EHS research so as to improve environmental public health in northern California, the Central Valley, and across the globe. Lein role: Leader, Career Development Program

PCB-Mediated Dysbiosis of the Gut Microbiome: A Missing Link in PCB-Mediated Neurodevelopmental Disorders?
R01 ES031098 Cui, Lehmler (Contact) and Lein (MPI) 02/01/2020 – 11/30/2024
The goal of this project is to test the central hypothesis that dysbiosis of the gut microbiome associated with developmental expo-sure to varying doses of PCBs contributes to adverse neurodevelopmental outcomes.

Traffic-Related Air Pollution Exacerbates AD-Relevant Phenotypes in a Genetically Susceptible Rat Model via Neuroinflammatory Mechanism(s)
RF1 AG074709 Lein (Contact) Bein and Van Winkle (MPI) 05/01/2021-04/30/2024
The main objective of the project is to test the hypothesis that TRAP decreases the time to onset and/or increases severity of Alzheimer's disease-like phenotypes in genetically susceptible individuals via microglial cell activation secondary to lung inflammation.

PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)
NIH/NIEHS R01 ES029213 (LaSalle/Lein/Schmidt) 06/01/18 - 05/31/23
This study leverages existing samples and behavioral outcome data from mice exposed perinatally to a mix of PCBs simulating the congener profile found in the serum of mothers in the MARBLES cohort with a new goal of identifying epigenetic placental biomarkers of PCB exposures and NDD risk. The unifying hypothesis is that genetic and PCB interactions can be detected as DNA methylation signatures in placenta to predict NDD.

Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication 
U54 NS079202 Lein (PI) 09/01/2012 - 05/31/2023 (NCE)
The unifying goal of the UC Davis CounterACT Center of Excellence is to identify improved medical countermeasures for treating acute intoxication with seizure-inducing chemical threat agents.

Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
NIH/NIA R01 AG056710 (Knowlton/Lein/Gelli) 03/15/18 - 02/28/23
The goal of this project is to test the hypothesis that senescent endothelial cells, which accumulate with aging, create a pro-inflammatory environment that adversely affects the blood brain barrier (BBB) and contribute to neuropathology implicated in age-associated dementias such as Alzheimer’s disease.

Neuronal Contribution to the Propagation of Inflammation in the Central Nervous System
R03 NS118156 (Seker) 08/01/2020-07/31/2022
The goal of this project is to generate preliminary data to support our central hypothesis that intra-axonal (antrograde and retrograde) signalling and electrophysiological signals (e.g., excitotoxicity) contribute to the transmission of neuroinflammatory triggers for the site of the insult to distal regions in the CNS.