Our Current Team
Professor of Neurotoxicology, Lab PI
Home town: Buffalo, NY
B.S. in Biology, Cornell University, 1981
M.S. in Environmental Health, East Tennessee State University, 1983
Ph.D. in Pharmacology and Toxicology, University of Buffalo, 1990
Postdoctoral Fellowship in Molecular Immunology, Roswell Park Cancer Institute, 1992
My research goal is to determine how environmental stressors interact with genetic susceptibilities to influence the risk and severity of neurodevelopmental disorders and neurodegeneration. Altered patterns of connectivity are associated with neurological deficits: therefore, my research program focuses on investigating how environmental contaminants, chemical convulsants and inflammation perturb neuronal connectivity as determined using biochemical, morphogenic and electrophysiological endpoints. We are also developing biomarkers of OP neurotoxicity and testing novel therapeutic approaches for protecting against the neurodegenerative effects associated with neurotoxic pro-convulsants.
Ana Cristina Goncalves Grodzki
I am originally from Curitiba, Brazil. At the Federal University of Parana I completed my undergraduate degree in Biology and met an amazing professor, Dr. Maria Celia Jamur who helped me to see science as a fun and fulfilling profession. During my PhD at Ribeirão Preto Medical School, University of São Paulo, I studied the progression of maturation and differentiation of mast cells in rodents and the process of migration of immature mast cells from bone marrow to the peripheral tissues. During my post-doctoral training at NIH, I was mentored by another outstanding scientist, Dr. Reuben Siraganian, and studied intracellular signal transduction pathways in mast cells that lead to the release of inflammatory molecules. Here at UC Davis, I am again under an amazing mentor, Dr. Pam Lein. In Dr. Lein’s lab I am a Project Scientist investigating the effects of organophosphorus pesticides (OPs) on nerve-immune cell interactions, specially implicated in airway hyperreactivity. This research will help us to understand how environmental factors influence susceptibility to airway disease. I am also the primary technical contact for the high content imaging equipment in Dr. Lein’s lab., which is part of the Biological Analysis Core of the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC). My time outside the lab is as fun and productive as the time inside lab. I enjoy traveling, being outdoors, and spending time with my family. My husband John and I have 2 bright and fun kids: Gabriela and Leo. And we all love to take care and have fun with our dog Zoey.
Academic Program Management Officer-Lab Manager
Home town: Shullsburg WI
Education: BS Creighton University
In our ever changing world there is a critical need to be able to respond quickly and effectively to exposures to neurotoxic chemicals. These chemicals may be released either accidentally or intentionally and have the potential for impacting large numbers of the population. Treatments must be developed to protect first responders and also minimize the neurological damage in individuals that survive the initial exposure. My research as part of the CounterACT project involves investigating novel neuroprotectants following acute exposures to organophosphates which are powerful acetylcholinesterase inhibitors or the rodenticide TETS which blocks GABAA receptors in the central nervous system. Our research indicates that anti-inflammatories and neural steroids may prove to be effective either alone or in combination to minimize the neural damage following acute intoxicant exposures.
In my role as lab manager I work with lab members to ensure that every one is working safely and efficiently.
When I am not in the lab I like spending time with my wife and dogs, creating stained glass and other objects of art, being outdoors, camping and going on the occasional bigfoot search.
Post Doctoral Scholar
Home town: Ottawa, Ohio
Ph.D. in Pharmacology and Toxicology, Brody School of Medicine at East Carolina University
M.S. in Biomedical Sciences, Brody School of Medicine at East Carolina University
B.S. in Biology with honors, Wittenberg University
In 2012 I received my B.S. in Biology from Wittenberg University in Springfield, Ohio, where I gained research experience in Physics and Neuropsychology. Following graduation, I worked toward my M.S. in Biomedical Sciences and Ph.D. in Pharmacology and Toxicology in the lab of Dr. Jamie DeWitt at the Brody School of Medicine at East Carolina University in Greenville, North Carolina. My graduate research was centered in developmental neuroimmunotoxicology and the developmental origin of adult disease. Specifically, I investigated the effect of postnatal lead exposure on microglial dysfunction and its role in the exacerbation of Alzheimer's disease.
I joined the labs of Dr. Pamela Lein and Dr. Michele La Merrill in the Fall of 2017 as a postdoctoral scholar. My current research directive is to explore sympathetic nervous system dysfunction in a rodent model of type II diabetes following exposure to the ubiquitous pesticide DDT.
When not in the lab, I enjoy astronomy, dance in all forms, art, awesome music, going to concerts, and hanging out with my two dogs.
Post Doctoral Scholar
I grew up in La Crosse, WI and attended college at the University of Colorado in Boulder where I majored in Molecular, Cellular, and Developmental biology. During that time, I received a summer undergraduate Cancer Research Fellowship from the University of Colorado Cancer Center where I got my first real taste of research. I next took a break from school to work in industry for a couple of years, which gave me valuable training and experience in the areas of food safety and aquatic toxicology. I joined the Graduate Group in Immunology at the University of California, Davis, in the fall of 2012 where I am working on projects related to the NIEHS Center for Childrens Environmental Health in the laboratories of Dr. Pam Lein and Dr. Judy Van de Water. My current research interests and projects lie in understanding interactions between the immune system and the nervous system and how these contribute to neurodevelopmental disorders such as autism. I am also interested in the areas of immunotoxicology and cancer immunotherapy. I have joined the Designated Emphasis in Biotechnology program to help fulfill my career goals. Outside of the lab, I enjoy the great outdoors (hiking, skiing, camping), cooking, concerts/music, and comedy.
Home town: San Lorenzo, CA
Education: B.S. in Environmental Science & Toxicology, UC Davis, 2016
My interest in biomedical research began with my undergraduate training in environmental and molecular toxicology. During this time, I completed an honors thesis elucidating mechanisms of DDT-induced mammary carcinogenesis. Upon graduation I decided to join the Lein lab as a laboratory technician to explore my interest in neurotoxicology; I am now continuing in the lab as a PhD student in the Pharmacology and Toxicology Graduate Group. My dissertation research focuses on evaluating the developmental neurotoxicity of pesticide and chemical threat agent DFP. By using MRI, PET, and histological imaging techniques I hope to characterize the spatiotemporal pattern of neurological damage resulting from acute DFP exposure during critical windows of neurodevelopment.
My hobbies outside of the lab include hip-hop and Latin dancing, Super Smash Bros., backpacking, and anything outdoors.
Staff Research Associate
Home town: Antioch, CA
B.S. in Neurobiology, Physiology and Behavior, UC Davis, 2005
M.S. in Animal Behavior: Physiological Bases of Animal Behavior, UC Davis, 2008
I’m a lifetime Aggie. I earned both my B.S. and M.S. at UC Davis, and I’ve been a member of the research staff since 2008. My research background is in neurobiology, animal behavior, pharmacology and toxicology. I work on a variety of projects in the Lein Lab, performing laboratory rodent research, histological analysis and analytical chemistry.
In my free time, I enjoy science fiction and fantasy stories, video games and home improvement projects.
Home town: Taipei, Taiwan
Education: B.S. in Medical Laboratory Science & Biotechnology, Taipei Medical University, 2014
I am a graduate student in the Molecular, Cellular, and Integrative Physiology Graduate group. I grew up in Taipei, Taiwan and I graduated from Taipei Medical University in 2014 with a B.S. in Medical Laboratory Science & Biotechnology. I gained profound interest in biomedical research when I got an internship opportunity to experience as a clinical intern at Cathay General Hospital, Taipei. With the clinical experience shared with clinical colleagues and interactions with patients acquired, I can bridge the connection between knowledge I learned from textbooks with the actual clinical data and phenomena that appear on patients. It was a truly precious experience for that I understand the importance of the advancement of medical science profoundly. Therefore, before starting graduate school, I worked as a lab technician in Dr. Lin’s lab from the School of Medical Laboratory Science and Biotechnology. There, my research interest focused on understanding important factors that affect neurodegenerative disorders such as Alzheimer’s disease and Huntington’s disease.
Under the CounterACT project, my research focuses on investigating the relationship between signs of cellular senescence and OPs following exposure to OPs.
In my free time, I enjoy hanging out with my friends, reading, and cooking.
Home town: Missoula, MT
Education: B.S. in Neuroscience, B.S. in Psychology // Washington State University Vancouver
I am a graduate student in the Pharmacology and Toxicology Graduate Group here at UC Davis. Prior to attending graduate school, I spent 8 years in the US Navy where I realized that more research was needed on how prescription drugs or chemical exposure can alter the behavior of humans. I returned to university in 2013 to study the biology and psychology of the brain at Washington State University, where I performed research developing rodent behavioral models for preclinical pain studies. I came to UC Davis and joined the Lein Lab in 2016 to continue learning about how drug or chemical exposure can affect the brain to alter behavior or produce neuropathology.
When I’m not in the lab I am usually spending time with my wife, Caitlin, and our kids, Jacob and Liliana. We enjoy climbing, hiking, biking, camping, and fishing.
Home town: Sonoma, CA
I am a PhD student in the Pharmacology and Toxicology graduate group. One of my long-term scientific interests is to understand how environmental exposures influence health, and my research in the Lein lab is focused on how chronic exposure to air pollution modifies neuroinflammation and neurodegeneration.
Outside of lab, I enjoy being outdoors - especially in the Sierras."
Home town: Soest, Germany / Los Angeles, CA
Education: B.S. in Biochemistry, Minor Mathematics, California State University, Los Angeles
I am a PhD student in the Pharmacology and Toxicology graduate group. My thesis project in the Lein lab focuses on understanding the developmental neurotoxic potential of halogenated pyrroles. Halopyrroles have been recently isolated in wastewater treatment sites as disinfection byproducts, but are not well-characterized in terms of their toxicity profile and potential risk to human populations. I am using the zebrafish model to determine whether halopyrroles are developmental neurotoxicants in vivo, and if so, whether this developmental toxicity is mediated by RyR-dependent mechanism(s). Fundamentally as a scientist, I am interested in understanding the influence of environmental insults during development on human health and cognition.
Outside of lab, I enjoy ballroom dancing, cooking traditional Armenian as well as German food, trying every escape room in town, and spending time with friends and family.
Felipe da Costa Souza
Post Doctoral Scholar
Home town: São Paulo, SP – Brazil
B.S in Biological science, Paulista University – UNIP (SP, Brazil); M.S. in Cell and Tissue biology, University of São Paulo – USP (SP, Brazil),
Ph.D. in Cell and Tissue biology, University of São Paulo – USP (SP, Brazil), 2017
I was born and raised in São Paulo, Brazil, where I also completed my degrees. During my Ph.D., and under the mentoring of Dr. Alison Colquhoun (USP – Brazil), my research focused on understanding how polyunsaturated fatty acid metabolism through the lipoxygenase pathway promotes cell proliferation, migration, and survival in central nervous tumors. We found interesting data regarding omega-6 linoleic acid (LA) metabolism on glioblastomas. A large part of my postgraduate training also focused on teaching. After my Ph.D, my scope moved from brain tumors toward neurobiology as I worked as a project scientist/lab manager performing neuroanatomical analysis while working with respiratory neural control in an animal model of Parkinson's disease. During this great time period, I learned a lot under the supervision of Dr. Ana Carolina Takakura and Dr. Thiago Moreira (USP – Brazil). In 2019, I had the incredible opportunity to join the labs of Dr. Ameer Taha and Dr. Pamela Lein as a postdoctoral scholar, combining the study of fatty acids and neurobiology. My current research is to understand how bioactive oxidized LA metabolites (OXLAMs) from dietary LA can influence and shape proper neurodevelopment.
Outside the lab, my hobbies include cooking, photography, oil painting, working out outdoors, science fiction and fantasy books/movies, and all sorts of nerdy things. I also study the philosophy of Zen Buddhism and Zen meditation, which I try to apply on my everyday life.
Home town: Elk Grove, CA
Education: B.S. in Pharmaceutical Chemistry, UC Davis, 2018
Research interests: I’m a current Master’s student in the Pharmacology and Toxicology program. My research interests include the use of psychotropic drugs as a way to treat PTSD and other mental illnesses as well as pesticides and their effects on the neurobiology. My background in pharmaceutical chemistry led me to the Lein lab as a way to further develop my knowledge in neuropharmacology. My current project is within the CounterACT group looking at temporal profiles of inflammatory biomarkers to determine the optimal time to administer neuroprotectives to ward off long term cognitive decline.
My hobbies outside of the lab include vintage auto racing, bonsai, and traveling with my girlfriend Sydney.
Education: B.S. in Chemistry, Northern Kentucky University, 2017
At Northern Kentucky University, I earned a B.S. in chemistry and a minor in criminalistics. As an undergraduate, I began to develop my skills as a chemist, while taking courses to join the field of forensic science. I worked in an organic chemistry lab focusing on synthesis of macrocyclic compounds. After graduation, I worked in an analytical chemistry lab determining the concentrations of active ingredients in skin and hair care products.
I moved to California from Cincinnati, Ohio in the fall of 2018, where I started on a M.S. in forensic science at UC Davis. I am studying both forensic biology and forensic chemistry. However, my primary interest is in forensic toxicology.
I am broadening my knowledge of toxicology by working in Dr. Lein’s Lab and studying neurotoxicology. I hope to use the knowledge and skills from neurotoxicology research to aid a career in forensic toxicology.
Home town: Walnut Creek, CA
Education: B.S. Biochemistry and Molecular Biology, UC Davis
I am currently a graduate student in the Pharmacology and Toxicology graduate program, but I have been involved in the field of neuroscience since my undergraduate education, which culminated in an honors thesis about the effect of maternal immune activation on cognitive development. In the Lein lab I hope to characterize the role of neuroinflammation in chemical exposures and to help identify neuroprotective compounds to prevent the long term cognitive decline associated with these exposures.
Outside of the lab I enjoy cooking fancy meals, driving my cat insane, camping in my hammock, and embarrassing myself attempting to play every sport with my wife, Angela.
Home town: Mars, PA
B.S. Marine and Molecular Biology, Saint Francis University
Ph.D., Molecular Cellular, and Integrative Physiology, UC Davis
I am interested in environmental health problems, and how fish can help us solve them. The focus of my Ph.D. was to investigate physiological and transcriptomic effects of various stressors on numerous fish species. I worked on several diverse projects including osmoregulatory differences between two populations of a threatened species, the Sacramento splittail, and the neurotoxic effects of pesticides on the critically endangered species, Delta smelt.
As a postdoc in the Lein lab, I am working with the CounterACT group to investigate GABA-A receptor subunit selectivity in TETs-induced seizures using zebrafish.
Outside of the lab I enjoy running, playing soccer, hiking and camping, and baking.