Lein Lab: Our most valuable asset - the people who work here

Our Current Team

Dr Pam Lein

Pam Lein

Professor of Neurotoxicology, Lab Principal Investigator

Home town: Buffalo, NY
Education: B.S., Biology, Cornell University
M.S., Environmental Health, East Tennessee State University
Ph.D., Pharmacology and Toxicology, University of Buffalo
Postdoctoral Fellowship, Molecular Immunology, Roswell Park Cancer Institute

My research goal is to determine how environmental stressors interact with genetic susceptibilities to influence the risk and severity of neurodevelopmental disorders and neurodegeneration. Altered patterns of connectivity are associated with neurological deficits: therefore, my research program focuses on investigating how environmental contaminants, chemical convulsants and inflammation perturb neuronal connectivity as determined using biochemical, morphogenic and electrophysiological endpoints. We are also developing biomarkers of OP neurotoxicity and testing novel therapeutic approaches for protecting against the neurodegenerative effects associated with neurotoxic pro-convulsants.

Dr. Lein is affiliated with the following graduate groups: Pharmacology and ToxicologyMolecular, Cellular and Integrative PhysiologyNeuroscienceImmunologyForensic Sciences. Dr. Lein is also a mentor for the Advancing Diversity in Neuroscience Research (ADNR) Honors Program at UC Davis, which supports diverse upper division undergraduate students who plan to pursue a PhD in neuroscience. 

Email: pjlein@ucdavis.edu

Dr Ana Cristina Goncalves Grodzki

Ana Cristina Goncalves Grodzki

Associate Project Scientist

Home town: Curitiba, Brazil
Education: B.S., Biology, Federal University of Parana
Ph.D., Ribeirão Preto Medical School, University of São Paulo
Postdoctoral Fellowship, Immunology, NIH, Bethesda, MD

While at the Federal University of Parana, I met an amazing professor, Dr. Maria Celia Jamur who helped me to see science as a fun and fulfilling profession. During my PhD at Ribeirão Preto Medical School, University of São Paulo, I studied the progression of maturation and differentiation of mast cells in rodents and the process of migration of immature mast cells from bone marrow to the peripheral tissues. During my post-doctoral training at NIH, I was mentored by another outstanding scientist, Dr. Reuben Siraganian, and studied intracellular signal transduction pathways in mast cells that lead to the release of inflammatory molecules. Here at UC Davis, I am again under an amazing mentor, Dr. Pam Lein. In Dr. Lein’s lab I am a Project Scientist investigating the effects of organophosphorus pesticides (OPs) on nerve-immune cell interactions, specially implicated in airway hyperreactivity. This research will help us to understand how environmental factors influence susceptibility to airway disease. I am also the primary technical contact for the high content imaging equipment in Dr. Lein’s lab., which is part of the Biological Analysis Core of the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC). My time outside the lab is as fun and productive as the time inside lab. I enjoy traveling, being outdoors, and spending time with my family. My husband John and I have 2 bright and fun kids: Gabriela and Leo. And we all love to take care and have fun with our dog Zoey.

Email: cgrodzki@ucdavis.edu

Donald Bruun

Donald Bruun

Academic Program Management Officer-Lab Manager

Home town: Shullsburg WI
Education: B.S., Creighton University

In our ever changing world there is a critical need to be able to respond quickly and effectively to exposures to neurotoxic chemicals. These chemicals may be released either accidentally or intentionally and have the potential for impacting large numbers of the population. Treatments must be developed to protect first responders and also minimize the neurological damage in individuals that survive the initial exposure. My research as part of the CounterACT project involves investigating novel neuroprotectants following acute exposures to organophosphates which are powerful acetylcholinesterase inhibitors or the rodenticide TETS which blocks GABAA receptors in the central nervous system. Our research indicates that anti-inflammatories and neural steroids may prove to be effective either alone or in combination to minimize the neural damage following acute intoxicant exposures.
In my role as lab manager I work with lab members to ensure that every one is working safely and efficiently.
When I am not in the lab I like spending time with my wife and dogs, creating stained glass and other objects of art, being outdoors, camping and going on the occasional bigfoot search.

Email: dabruun@ucdavis.edu

Anthony Valenzuela

Anthony Valenzuela

Staff Research Associate

Home town: Antioch, CA
Education: B.S., Neurobiology, Physiology and Behavior, UC Davis
M.S., Animal Behavior: Physiological Bases of Animal Behavior, UC Davis

I’m a lifetime Aggie. I earned both my B.S. and M.S. at UC Davis, and I’ve been a member of the research staff since 2008. My research background is in neurobiology, animal behavior, pharmacology and toxicology. I work on a variety of projects in the Lein Lab, performing laboratory rodent research, histological analysis and analytical chemistry.   

In my free time, I enjoy science fiction and fantasy stories, video games and home improvement projects.

Email: aevalenzuela@ucdavis.edu

Yi-Hua Tsai

Yi-hua Tsai

Postdoctoral Fellow

Home town: Taipei, Taiwan
Education: B.S., Medical Laboratory Science & Biotechnology, Taipei Medical University

I grew up in Taipei, Taiwan and graduated from Taipei Medical University in 2014 with a B.S. in Medical Laboratory Science & Biotechnology. I gained profound interest in biomedical research when I got an internship as a clinical intern at Cathay General Hospital, Taipei. This experience allowed me to bridge the knowledge I learned from textbooks with actual clinical data and phenomena that appear in patients.  I next worked as a lab technician in Dr. Lin’s lab from the School of Medical Laboratory Science & Biotechnology. There, my research interest focused on understanding important factors that affect neurodegenerative disorders, such as Alzheimer’s disease and Huntington’s disease. I went on to receive a PhD in Molecular, Cellular, and Integrative Physiology at UC Davis, where I investigated the pathogenic mechanisms of long-term neurotoxicity following repeated low-level and acute high-level organophosphate intoxication. I am furthering my work on the functional relationship between pathogenic mechanisms, such as oxidative stress and cellular senescence, following acute organophosphate intoxication as a postdoc in the lab.

In my free time, I enjoy hanging out with my friends, reading, and cooking.

Email: yihtsai@ucdavis.edu

Bianca Yaghoobi

Bianca Yaghoobi

Graduate Student

Home town: Soest, Germany / Los Angeles, CA
Education: B.S., Biochemistry, Minor Mathematics, California State University, Los Angeles

I am a PhD student in the Pharmacology and Toxicology graduate group. My thesis project in the Lein lab focuses on understanding the developmental neurotoxic potential of halogenated pyrroles. Halopyrroles have been recently isolated in wastewater treatment sites as disinfection byproducts, but are not well-characterized in terms of their toxicity profile and potential risk to human populations. I am using the zebrafish model to determine whether halopyrroles are developmental neurotoxicants in vivo, and if so, whether this developmental toxicity is mediated by RyR-dependent mechanism(s). Fundamentally as a scientist, I am interested in understanding the influence of environmental insults during development on human health and cognition.

Outside of lab, I enjoy ballroom dancing, cooking traditional Armenian as well as German food, trying every escape room in town, and spending time with friends and family.

Email: byaghoobi@ucdavis.edu

Peter Andrew Image

Peter Andrew

Graduate Student

Home town: Arlington, VA
Education: B.S., Biology and Psychology, Tufts University
 
I am a student in the Pharmacology and Toxicology graduate group. I grew up in Virginia, and completed my undergraduate education at Tufts University in Massachusetts. As an undergraduate I was introduced to the field of pharmacology through my thesis project exploring the interaction between stress and ethanol abuse. After graduating, I worked for two years as a technician in the Tufts-AstraZeneca Laboratory for Basic and Translational Neuroscience. My research in the Lein Lab involves the assessment of neuroprotective strategies against intoxication with organophosphates. 
Outside of the lab, I enjoy biking and all things food. 
 
Email: pandrew@ucdavis.edu

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Felipe da Costa Souza

Postdoctoral Fellow

Home town: São Paulo, SP – Brazil
Education: B.S., Biological science, Paulista University – UNIP (SP, Brazil); M.S., Cell and Tissue Biology, University of São Paulo – USP (SP, Brazil)
Ph.D., Cell and Tissue Biology, University of São Paulo – USP (SP, Brazil)

I was born and raised in São Paulo, Brazil, where I also completed my degrees. During my Ph.D., and under the mentoring of Dr. Alison Colquhoun (USP – Brazil), my research focused on understanding how polyunsaturated fatty acid metabolism through the lipoxygenase pathway promotes cell proliferation, migration, and survival in central nervous tumors. We found interesting data regarding omega-6 linoleic acid (LA) metabolism on glioblastomas. A large part of my postgraduate training also focused on teaching. After my Ph.D, my scope moved from brain tumors toward neurobiology as I worked as a project scientist/lab manager performing neuroanatomical analysis while working with respiratory neural control in an animal model of Parkinson's disease. During this great time period, I learned a lot under the supervision of Dr. Ana Carolina Takakura and Dr. Thiago Moreira (USP – Brazil). In 2019, I had the incredible opportunity to join the labs of Dr. Ameer Taha and Dr. Pamela Lein as a postdoctoral scholar, combining the study of fatty acids and neurobiology. My current research is to understand how bioactive oxidized LA metabolites (OXLAMs) from dietary LA can influence and shape proper neurodevelopment.

Outside the lab, my hobbies include cooking, photography, oil painting, working out outdoors, science fiction and fantasy books/movies, and all sorts of nerdy things. I also study the philosophy of Zen Buddhism and Zen meditation, which I try to apply on my everyday life.

Email: fesouza@ucdavis.edu

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Jeremy MacMahon

Graduate Student

Home town: Walnut Creek, CA
Education: B.S., Biochemistry and Molecular Biology, UC Davis

I am currently a graduate student in the Pharmacology and Toxicology graduate program, but I have been involved in the field of neuroscience since my undergraduate education, which culminated in an honors thesis about the effect of maternal immune activation on cognitive development. In the Lein lab I hope to characterize the role of neuroinflammation in chemical exposures and to help identify neuroprotective compounds to prevent the long term cognitive decline associated with these exposures.

Outside of the lab I enjoy cooking fancy meals, driving my cat insane, camping in my hammock, and embarrassing myself attempting to play every sport with my wife, Angela.

email: jamacmahon@ucdavis.edu

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Paige Mundy

Postdoctoral Fellow

Home town: Mars, PA
Education: B.S., Marine and Molecular Biology, Saint Francis University
Ph.D., Molecular Cellular, and Integrative Physiology, UC Davis

I am interested in environmental health problems, and how fish can help us solve them. The focus of my Ph.D. was to investigate physiological and transcriptomic effects of various stressors on numerous fish species. I worked on several diverse projects including osmoregulatory differences between two populations of a threatened species, the Sacramento splittail, and the neurotoxic effects of pesticides on the critically endangered species, Delta smelt.

As a postdoc in the Lein lab, I am working with the CounterACT group to investigate GABA-A receptor subunit selectivity in TETs-induced seizures using zebrafish.

Outside of the lab I enjoy running, playing soccer, hiking and camping, and baking.

email: pacmundy@ucdavis.edu

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Mei-Yun Tang

Graduate Student

Home town: Palo Alto, CA
Education: B.S., Animal Science, UC Davis

I am a PhD student in the Molecular, Cellular and Integrative Physiology graduate group. As a third-year undergraduate, I was first introduced to biomedical research through joining the Lein lab as a research intern in CounterACT and completing an honors thesis on the evaluation of neurogenesis in a juvenile rat model of acute organophosphate intoxication. Upon graduation, I continued working in the lab as a junior research specialist investigating the role of the plasminogen activator system (PAS) as a biomarker and therapeutic target for mitigating neuroinflammation in a transgenic rat model of Alzheimer’s disease (AD).

As a graduate student, I am continuing my studies of the PAS in AD - specifically in its association with the neuroinflammatory response and in altering the blood-brain barrier (BBB). I am interested in its role as a mediator between the CNS and peripheral inflammation. Additionally, I will be determining the impact of traffic-related air pollution (TRAP) on modulation of BBB integrity, microglial and astroglial activation, and AD-relevant pathology in the same transgenic rat model. Over the course of my scientific training, I hope to elucidate potential mechanisms of TRAP-induced neuroinflammation and BBB dysfunction.

Outside of the lab, I love serving in college ministry at my church, enjoying the outdoors, all things music, and going to coffee shops. Feel free to email me if you’d like to connect!

email: mytang@ucdavis.edu

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Rebecca Wilson

Graduate Student

Home town: Livonia, MI
Education: B.S., Biology with Honors, Roosevelt University, Chicago
M.S. Biological Sciences, Neuroscience, DePaul University

In 2015, I received my B.S. majoring in biology and minoring in chemistry and calculus from Roosevelt University, where I first fell in love with doing research. Initially, I worked in glaucoma research with Dr. Kelly Wentz-Hunter assessing possible RNA responsible for alterations in the trabecular meshwork of the eye. I also conducted ecological restoration research in Tanzania, Africa, on the Amani Nature Reserve with Dr. Norbert Cordeiro measuring seed rain. Following graduation, I worked towards my M.S. in biological sciences with a focus in neuroscience under the watchful eye of Dr. Dorothy Kozlowski in Chicago. In this lab, I completed my thesis assessing sex differences in behavioral responses to repeat subconcussive injuries. Afterward, I had the opportunity to work for a pharmaceutical research company, Aptinyx, introducing and optimizing animal models of neurodegeneration for use with their compounds. I joined the lab of Pam Lein during the Summer of 2020. My current research directive is focused on the effect of PCBs on neurodevelopment and how modulation of the metabolism of PCBs may alter neurotoxic outcomes. I will be looking in vitro and in vivo to better elucidate the mechanism of PCBs involvement in cellular and behavioral outcomes following exposure. 

When not in the lab I enjoy reading, spending time with my dog, going on trips, and cooking! 

Email: rjwilso@ucdavis.edu

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Ryan Hogans

Graduate Student

Home town: Carmel Valley, CA
Education: B.S., Biology, Northern Arizona University

I am a graduate student in the Molecular, Cellular and Integrative Physiology (MCIP) graduate group. My interest as a scientific investigator is in the determinants of disease etiology. As an undergraduate researcher I studied molecular genetics with Dr. Nathan Nieto. We investigated the prevalence of intracellular pathogens in threatened Arizona wildlife. Prior to attending graduate school, I worked in industry biotechnology developing molecular diagnostics tools and therapeutics to study and utilize the biology of small nucleic acids.

As a graduate student in the Lein lab I will be investigating factors secreted by cells in the brain during aging that increase susceptibility to neuroinflammation and neurodegeneration. Circulating biomolecules play many important roles in physiology. By describing the molecular and cellular actors at play in the brain during advanced age, we can refine our understanding of neurodegenerative diseases for which age is the primary risk factor.

Outside of my studies I love to spend my time playing jazz and blues, or biking and hiking where I can spot wildlife.

Email: rehogans@ucdavis.edu

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Jessie Badley

Graduate Student

Home town: San Francisco Bay Area, CA
Education: B.S., Biochemistry, UC Davis

I was born and raised in the San Francisco Bay Area and am definitely a product of my environment. I am a proud first-generation student and UC Davis Aggie. I transferred to U.C. Davis in my junior year, obtaining my B.S. in Biochemistry in 2020 and have been working in labs for the last four years. I am currently a PhD student in the Pharmacology and Toxicology graduate group. My undergraduate research focused on method development and metabolomics in Dr. Oliver Fiehn’s lab. I joined the Lein lab in Winter 2021, and my current research focus is the CYP-mediated metabolism and biotransformation of PCBs and how modifying these metabolic pathways effects neurological development.

I am an ex-pastry chef, rare plant collector, dog enthusiast (especially my dog, Boscoe), crafting connoisseur, and avid bike rider. I am extremely blessed to have gotten this far in my education and hope to bring a diverse perspective to my PhD studies. My goal is to not only push the boundaries of science and research, but also advocate for those underserved and underrepresented.

Email: jrbadley@ucdavis.edu

An Nguyen

An Nguyen 

Junior Specialist

Hometown: Petaluma, CA
Education: B.S., Biochemistry and Molecular Biology, UC Davis

I am a recent UC Davis graduate and earned my B.S in Biochemistry and Molecular Biology in Spring of 2021. I joined the Lein Lab during my junior year and was involved in the CounterACT research project. During my senior year, I completed my honors thesis on the characterization region specific neuropathology of tetramethylenedisulfotetramine (TETS)-induced seizures in mice. Currently as a junior lab specialist, I am continuing my involvement with the CounterACT project by pivoting my research focus on the neuropathology and mechanism of diisopropyl fluorophosphate (DFP) induced seizures.

Outside of lab I enjoy cooking, doing elaborate baking projects, turning my indoor spaces into an urban jungle by collecting plants, and reading books ranging from fantasy to science.

Email: anbnguy@ucdavis.edu

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Xiuzhen Liu

Postdoctoral Fellow

Hometown: China
Education: B.S., Nutrition Science, UC Davis

Ph.D., Nutritional Biology emphasizing in Neuroscience, UC Davis

While I was in graduate school at UC Davis, I was working on two projects: 1) the effects of maternal zinc deficiency on brain development, and 2) the effects of environmental toxicants exposure on zinc metabolism and the consequence on brain development during pregnancy.  My current research is focusing on CounterACT projects involving in diisopropyl fluorophosphate (DFP) induced seizure, neuroinflammation and neurodegeneration.

During my free time, I enjoy cooking, gardening, and spending time with my children.

Email: xiuliu@ucdavis.edu

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Pedro Negri Bernardino

Graduate Student

Home town: Piracicaba, São Paulo, Brazil
Education: DVM, São Paulo State University (UNESP – Botucatu)
M.S., General Veterinary Medicine/emphasis in Clinical Microbiology, São Paulo State University (UNESP – Botucatu)

I am a PhD student in the Graduate Group in Integrative Pathobiology. During vet school, I worked in two different labs where I learned multiple techniques in cellular and molecular biology, studying the prevalence of genetic diseases in buffaloes in one lab and the immunomodulatory properties of natural compounds in the other. After my residency in Large Animal Internal Medicine, I earned my Master’s degree with a focus on microbiology, studying the effects of natural and synthetic compounds against Corynebacterium pseudotuberculosis.

My main career goal is work in translational research, where I can bring bench work findings to the clinical field. Joining the Lein Lab will enable me to gain skills with animal models while studying the pathogenesis and the real world problem of epilepsy due to organophosphate intoxication.

Email: pnberna@ucdavis.edu

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Zabrisky Roland 

Junior Specialist

Hometown: Livermore, CA
Education: B.S., Neurobiology, Physiology and Behavior, UC Davis

I recently completed my undergraduate degree in Neurobiology, Physiology and Behavior at UC Davis. During my last year, I worked as an undergraduate research assistant in the Lein laboratory. Fascinated by the research, I joined as a Junior Specialist after graduating. 

I am primarily involved with the Alzheimer’s disease (AD) subgroup, and my interests include the effects of environmental factors on progression of the disease. AD is multifactorial in its progression and destructive in its manifestation. I hope that a focus on progression may help identify targets for more effective treatments.

In my free time, I enjoy hiking, climbing, playing music, games, and spending time with family and friends.

Email: zroland@ucdavis.edu

Ilknur Dursun

Ilknur Dursun 

Postdoctoral Fellow

Hometown: Tunceli, Turkey
Education: B.S., Biology, Ankara University, Turkey
M.S., Biological Sciences, Middle East Technical University, Ankara / Turkey
Ph.D., Biological Sciences, Middle East Technical University, Ankara Turkey

I received my B.S. from Ankara University, Department of Biology, in 2000, and then started working as a research assistant in the Department of Biological Sciences at the Middle East Technical University (METU) in 2002. I received a MSc degree with a focus on "Effects of Prenatal Alcohol Exposure on Activity, Anxiety and Learning In Young Adult Wistar Rats ". In 2005, I conducted research for 3 months with scholarships from Louisiana State University, Health Sciences Center, Cell Biology and Anatomy Department and METU. Between 2007-2009, I joined the UC Davis Department of Neurobiology, Physiology and Behavior and Neuroscience Center to conduct doctoral thesis work in collaboration with METU. My PhD thesis was "The Effects of Early Postnatal Ethanol Intoxication on Retina Ganglion Cell Morphology and the Development of Retino-Geniculate Projections In Mice”. Since 2012, I have worked as an assistant professor in Istanbul. As of November 2020, I joined the School of Medicine at Istanbul Istinye University, Department of Physiology as a faculty member. My research focuses on models of teratology during the pre/postnatal period. Within the scope of preclinical studies, I have experience with behavioral tests that examine learning and memory, anxiety, locomotor activity, and depression by using very broad behavioral tasks. I also have performed quantitative neuroanatomical examination of brain tissue images following immunohistochemistry or other staining methods.

Outside of lab, I enjoy biking, hiking, cooking, reading, knitting, spending time with friends and travel.

Email: idursun@ucdavis.edu

Lukas Skuja

Lukas Skuja

Graduate Student

Hometown: Oakland, CA
Education: B.S., Neuroscience, Brown University

I'm a PhD student in the Neuroscience Graduate Group and working with Denali Therapeutics through the UC Davis Advanced Degree Program for Corporate Employees. Thus, I'm being co-mentored by Dr. Pamela Lein at UC Davis and Dr. Gilbert Di Paolo at Denali Therapeutics. My research interests are aimed at better understanding the molecular and cellular mechanisms that underlie neurodegeneration - with the ultimate goal to help patients affected by neurodegenerative diseases. Some adjacent areas of interest include neuroinflammation, lysosomal dysfunction, and neurovasculature biology.

I was born and raised in Oakland, love the Bay, and rep it along with the Golden State Warriors. I like watching and playing sports/games generally, and especially love getting out in nature - hiking, skiing, whitewater kayaking... I've worked as a whitewater river rafting guide for a good chunk of time and actually spent about 6 months in New Zealand after undergrad working, traveling, and living in a van down by the river!

Email: llskuja@ucdavis.edu

Suzette Smiley-Jewell

Suzette Smiley-Jewell 

Scientific Program Manager

Hometown: San Jose, CA
Education: B.S., Environmental Toxicology, UC Davis
Ph.D., Pharmacology and Toxicology, UC Davis

My primary job is serving as the Scientific Program Manager for the UC Davis CounterACT Center of Excellence. However, I enjoy using my skills as a scientific editor and web content manager to help out in the Lein lab. In the past, I served as a Principal Editor for the Center for Health and Environment and as an Academic Coordinator at the Center for Neuroscience, where I managed two NIH T32 graduate student training grants. While I didn't always enjoy the ups and downs of doing experiments, I've always loved learning about science and helping people get their results published and ideas funded.

Outside of lab, I enjoy being with friends and family, exercising, gardening and chasing around my 2 dogs and 3 hens.

Email: smsmiley@ucdavis.edu