Pam Lein

Professor of Neurotoxicology, Lab PI

Home town: Buffalo, NY
B.S. in Biology, Cornell University, 1981
M.S. in Environmental Health, East Tennessee State University, 1983
Ph.D. in Pharmacology and Toxicology, University of Buffalo, 1990
Postdoctoral Fellowship in Molecular Immunology, Roswell Park Cancer Institute, 1992

Personal Scientific Statement:
My research goal is to determine how environmental stressors interact with genetic susceptibilities to influence the risk and severity of neurodevelopmental disorders and neurodegeneration. Altered patterns of connectivity are associated with neurological deficits: therefore, my research program focuses on investigating how environmental contaminants, chemical convulsants and inflammation perturb neuronal connectivity as determined using biochemical, morphogenic and electrophysiological endpoints. We are also developing biomarkers of OP neurotoxicity and testing novel therapeutic approaches for protecting against the neurodegenerative effects associated with neurotoxic pro-convulsants.